Naloxone is very safe and saves lives. It can be given to anyone showing signs of an opioid overdose, even if you are not sure if they have used opioids. Naloxone is not addictive and cannot be used to get high.
NARCAN® Nasal Spray is an easy-to-use nasal spray packaged with two spray bottles (atomizers) in case a second dose is needed. A Quick Start guide in the box gives instructions and should be read in advance. People receiving naloxone kits that include a syringe and naloxone ampules or vials should receive a brief training on how to use it.
Naloxone has been proven to be extremely safe, with no bad effects on the body if the person has not used opioids. Naloxone can also be used on pregnant women. Naloxone does not cause any life-threatening side effects.
People with physical dependence on opioids may have signs of withdrawal within minutes after they are given naloxone. But, this is normal and good because it means that the naloxone is helping the person to breathe again. Normal withdrawal symptoms can include headaches, changes in blood pressure, anxiety, rapid heart rate, sweating, nausea, vomiting, and tremors. These symptoms are not life threatening but can be uncomfortable.